Project Tycho includes data from all weekly notifiable disease reports for the United States dating back to 1888. These data are freely available to anybody interested. I wanted to play around with the data a bit, so I registered.MeaslesMeasles a... [Read more...]

Chapter 19 of Rowland and Tozer (Clinical pharmacokinetics and pharmacodynamics, 4th edition) has distribution kinetics. I am examining problem 3. It is fairly easy, especially since essentially all formulas are on the same page under 'key relationships'. The only difficulty is that the formulas are symmetrical in λ1, c1 and λ2, c2 and they ... [Read more...]

In this third PK posting I move to chapter 10, study problem 4 of Rowland and Tozer (Clinical pharmacokinetics and pharmacodynamics, 4th edition). In this problem one subject gets a 24 hours continuous dose. In many respects the Jags calculation is not very different from before, but the relation between parameters in the ... [Read more...]

I am examining IV and oral dosing of problem of Chapter 6, Question 6 or Roland and Tozer Rowland and Tozer (Clinical pharmacokinetics and pharmacodynamics, 4th edition) with Jags. In this problem one subject gets an IV and an oral dose.DataThe data lo... [Read more...]

In this post I want to analyze a first order pharmocokinetcs problem: the data of study problem 9, chapter 3 of Rowland and Tozer (Clinical pharmacokinetics and pharmacodynamics, 4th edition) with Jags. It is a surprising simple set of data, but still there is enough to play around with.Data, model and ... [Read more...]

Approximately a year ago I made a post graphing unemployment in Europe and other locations. I have always wanted to do this again, not because the R-code would be so interesting, but just because I wanted to see the plots. As time progressed I attempte... [Read more...]

Last week I extended my Bayesian model. So this week I wanted to test it with different data. There is one other data set with profiling data in R, french fries in the reshape package. 'This data was collected from a sensory experiment conducted at Iow... [Read more...]

Last week I made the core of a Bayesian model for sensory profiling data. This week the extras need to be added. That is, there are a bunch of extra interactions and the error is dependent on panelists and descriptors.Note that where last week I pointe... [Read more...]

I looked at Bayesian analysis of sensory profiling data in May and June 2012. I do remember not being totally happy with the result and computations taking a bit more time than I wanted. But now it is 2014, I can use STAN and I have been thinking about... [Read more...]

There were quite some reactions on lasts week's post converting plots to data. Two additional programs were mentioned; WebPlotDigitzier and DataThief. Note that google or wikipedia has a bunch of alternatives. Datathief is shareware, a java program, so... [Read more...]

It is a problem which occurs ever so often in applied work, you have a plot, but you want the data. There are at least two programs which can help you there; PlotDigitizer and Engauge Digitizer. I got both on my openSuse machine. Both are available for... [Read more...]

For my first experience with STAN I wanted to convert my last JAGS program into STAN. This was a bit more difficult than I expected. The JAGS program was Fe concentration in rainwater including values below detection level.DataData has been explained b... [Read more...]

This week I wanted to play around with Julia and exporting the results. I found http://xianblog.wordpress.com/2013/12/29/le-monde-puzzle-847/ to be just the right size to play around with. CodeA function to check if a triplet has the desired property In [1]: function lemonde847(xx) a=[xx[1],2] b=[xx[2],8] c=[... [Read more...]

In December my nice little netbook acquired a shiny new openSUSE 13.1, including all the goodies I might want to use in 2014; R, Stan, Julia and Jags. So here is what you might get when you set up a computer for statistics today.JagsI have been using J... [Read more...]

Sometimes I have the desire to plot both on the linear and on the log scale. To save space just two figures is not my solution. I want to reuse the x-axis, legend, title. This post examines possibilities to do so with standard plot tools, lattice and g... [Read more...]

Fukushima is still a topic which gets headlines, and somewhere in a comment was a link to actual and historical radiation data: Fukushima prefecture radioactivity measurement map.  It takes a bit of time to load but then you have a map of the Fukushima region with current radiation levels at ... [Read more...]

In my previous post I ignored the fact that some data are below the detection level. I would not know how to handle those in a mixed model from lme4 or nlme. However, JAGS can handle these values. Next to that I kept the usual independent variables, su... [Read more...]

Last week I examined rainwater composition 1992 to 2005. There is additional data, but National Institute for Public Health has changed equipment in 2005. This week I will add those data.DataData is in a number of spreadsheets. The scrip... [Read more...]

After reading Blog About Stats' Open Data Index Blog Post I decided to browse a bit in the Open Data Index. Choosing Netherlands and following Emission of Pollutants I ended on a page from National Institute for Public Health. The page&n... [Read more...]

Last week I looked at two-way cross-over studies and followed the example of Schütz (http://bebac.at/) in the analysis. Since the EU has its on opinions (Questions & Answers: Positions on specific questions addressed to the pharmacokinetics working party) and two example data sets, I was wondering how the ... [Read more...]